AutoReaGas was used for the simulations of premixed gas/air mixtures explosion characteristics in obstacle-filled tubes with a cross-section of 0.2 m×0.2 m and the length of 28 m. Numerical analyses provide a quantitative description of dependence of flame propagation speed and explosion overpressure on obstacles number, blockage ratio and interval distance. Computational results indicate that the obstacles play a significant role in determining the flame transmission speed and explosion overpressure in gas explosions. With the increase of blockage ratio, the explosion overpressure gradually rises. Nevertheless, the flame speed does not always increase along with increasing blockage ratio, but subsequently begins to decrease as the blockage ratio increases to some extend. Also, the interval distance between obstacles strongly influences flame behavior and explosion overpressure. When the obstacle interval distance is equal to inner diameter of the tube, the average flame speed in the obstacle zone and the peak overpressure in tube all reach maximum values.