[Objectives] The aim of this paper was to reveal the changes of large livestock industry and their influence on animal husbandry economy in Guyuan City of Ningxia. [Methods] The linear trend method was employed to quantify the change trends of the indicators for large livestock industry, and the ridge regression model was conducted to analyze their impacts on the gross output value of animal husbandry(GOVAH). [Results] The numbers of sold and slaughtered cattle and sheep in Guyuan presented a significant upward trend, while the number for hog had a significant downward trend, during 2000-2019. The GOVAH in Guyuan and its 5 counties had increased by 2-3 times in recent 20 years, which was mainly driven by large-scale livestock breeding. The cattle and sheep breeding sectors had positive effects on GOVAH, while the hog breeding sector had negative effect. [Conclusions] This study provides a reference for the structural adjustment and large-scale development of animal husbandry.