<正>Clear cell renal cell carcinoma is a common type of malignant kidney tumors,approximately accounting for 60%～85%in renal carcinoma.ccRCC is not sensitive to chemotherapy or radiotherapy,these therapies usually have great side-effect.Thus,it is very necessary to develop an effective therapeutic method.Sirt4 is located in mitochondria and represses the metabolism of glutamine into tricarboxylic acid cycle.