<正>Newt acidic fibroblast growth factor(nFGF-1)plays an important role in several cellular processes including cell growth,cell differentiation,angiogenesis,wound healing and other chemo tactic activities.Recently,nFGF-1 was cloned and expressed in E.Coli and the double labeled(~(15)N and ~(13)C)protein(nFGF-1)was prepared.A series triple resonance experiments were carried out.The NMR 3D structured of nFGF-1 was calculated by using distance-geometry calculation