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泌尿科学
Blockade of epithelial sodium channels improves spermmotility in asthenospermia patients
<正>ENaCs are important ion channels that paly important roles in physiology as well as pathophysiology.Inhibiting ENaCs using amiloride and its derivatives has been suggested in treatment of cardivascular disease and hypertension.By immunoblotting, we demonstrated the presence of ENaC-α protein in the flagellar midpiece of both rat and human sperm.Immunohistochemistry analyses in rat testis localized ENaC-α expressed in the Leydig cell,Sertoli's cell,Ap spermatogonium,spermatocyte, spermatid and residue body.Importantly,using computer-assisted sperm motility analysis(CASA),we first observed that EIPA inhibition of ENaCs,possibly including ENaC-α and ENaC-8,significantly improved the sperm motility in healthy donors by 14.23%(Mean±SEM,68.75±9.76% vs 78.53±6.20%,P<0.001)and in asthenospermia patients by 115.89% from 9.50±6.11% to 20.51±12.13%(Mean±SEM,P<0.001).The improved sperm motility by EIPA has important clinical implications in the treatment of asthenospermia and certainly warrant further investigation.
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湘鄂赣首届性与生殖健康学术研讨会论文汇编
2007年
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