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生物学
Frequency and Correlation of Nearest Neighboring Nucleotides in Human Genome
<正>One of the extremely urgent tasks that bioinformatics is now addressing is to find genetic rules and mathematics characteristics stored in DNA sequence.In this paper,the Zipf's approach in linguistics is utilized to analyze the statistical features of 16 nearest neighboring nucleotides(AA,AC,AG,...,TT)in 12 human chromosomes(Y,22,21,20,19,18,17,16,15,14,13,and 12).We find the statistical features of nearest neighboring nucleotides in human genome(i)frequency distribution follows the linear function, and(ii)correlation distribution follows the inverse function.Furthermore,the frequency and correlation distributions of nearest neighboring nucleotides depend on GC content in human chromosomes,our results show that the coefficients of linear function and inverse function depend on GC content.Our work proposes the correlation distribution of nearest neighboring nucleotides for the first time and extends the descriptor about nearest neighboring nucleotides.
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甘肃省化学会第二十五届年会、第七届甘肃省中学化学教学经验交流会论文集
2007年

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