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温度敏感原位凝胶中药物的扩散行为

魏刚;陆伟跃;郑俊民

  AimTo study the diffusion behaviors of drugs in thermosensitivein situgels, and provide valuable information for designing such delivery systems. MethodsA free diffusion model was used to evaluate the effects of concentration, the property of drugs, as well as the gel compositions on the diffusivity of drugs. ResultsDrug transport through the aqueous channels of the gel followed Fickian mechanism, and no significant influence on the diffusivity was observed when the drug concentration was lowered from 5% to 0.25%. The diffusion coefficients of propranolol, timolol maleate, and salbutamol sulfate were 0.91, 1.32, and 3.30×10-6cm2·s-1 , respectively. The flux of hydrophilic drug was 3.6 fold faster than that of the lipophilic one implied the latter partitioned into the hydrophobic micellar core, and consequently the diffusion was retarded. The diffusivity was decreased with increased poloxamer and sodium hyaluronate concentration, due to the distorted aqueous channels and higher microviscosity. ConclusionThe result suggested that sustained release could be achieved for the thermosensitivein situgel by incorporating lipophilic drug or increasing polymer concentration.……   
[关键词]:温度敏感凝胶;泊洛沙姆;扩散
[文献类型]:期刊
[文献出处]: 《药学学报2004年03期
[格式]:PDF原版; EPUB自适应版(需下载客户端)