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利用三溴化铟催化的Biginelli反应原位合成3,4-二氢嘧啶-2-酮

傅南雁;袁耀锋;庞美丽;王积涛

  A novel catalyst indium(Ⅲ) tribromide is shown to efficiently promote 5-carbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones from a three-component coupling of β-diketones, aldehydes and urea in ethanol. This modified one-pot Biginelli′s cyclocondensation not only features simple operation, but also takes place in nonpolluted environment. The structure of the Biginelli reaction product fromβ-diketones, salicylaldehyde and urea has been proposed to possess an oxygen-bridge.……   
[关键词]:Biginelli反应;三溴化铟;3;4-二氢嘧啶-2-酮;氧桥
[文献类型]:期刊
[文献出处]: 《高等学校化学学报2003年01期
[格式]:PDF原版; EPUB自适应版(需下载客户端)