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The Complement System in Liver Diseases


  The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver (mainly hepatocytes) is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety of complement receptors. Recent evidence from several studies suggests that the complement system is also involved in the pathogenesis of a variety of liver disorders including liver injury and repair, fibrosis, viral hepatitis, alcoholic liver disease, and liver ischemia/reperfusion injury. In this review, we will discuss the potential role of the complement system in the pathogenesis of liver diseases.……   
[关键词]:immunity;complement;liver disease
[文献类型]:期刊
[文献出处]: 《Cellular Molecular Immunology2006年05期
[格式]:PDF原版; EPUB自适应版(需下载客户端)