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中国南方汉族哮喘人群IgE高亲和力受体β链基因E237G突变与健康人群的对比研究

曾林祥

  Objecti\ ef To ana1yze the assoc1at 1on between Fc s RI-- Dgene E237G variant and asthma in the peoD1e of the Haflnat iona1 itv of south china.MethodsAmp1 1 fi cat iofl refractory mutat ion system PCR(:AR)IS--PCR) was used to determine Fc E RI-- D gene E237Gvariallt 1n 69 unre1ated pat 1 ents wi th asthma and 28 hea1 thycoritro1s frOm the peoD1e of the Han nationa1 f1ty of sotlth{h i na.ResLlltsf E2;37(i was detected in 8 subjects l rom 69d.thlnat ics (l l. 6%), afld l in 28 hea1t[1y contro1s (3. d796).The TreqLlenc }- of genot ype E237G 1oc i i n asthfl1at i c sG1 u/ G l }rgent)t Vpe accotlnt s tor 7. 2o9b, G1 y/ G1y genotype t:1. 3d9b andGl u (j1u 88.1ub. There was no significant ditference ifl thet reqtlence ot coding variaflt E237G 1n asthmat i cs or h1gh IgElnv.e1 group cofnpared wi th norTna1 group.Conclusion: We are unab1e to confirm that the Fc E RI-0 ge12e E237G variant is associated with asthma or IgE1evels in the peop1e of the Han nat1ona1 ity off South China.……   
[关键词]:FcεRI-- β gene;E237G variant;Susceptibility of asthma
[文献类型]:硕士论文
[文献出处]:江西医学院2000年