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Abnormal Suppressive Capacity and Decreased Quantity of CD4+CD25+ Regulatory T Cells Implicated in Cardiac Dysfunction Induced by Autoantibody against the Second Extracellular Loop of Beta1-Adrenoceptor

Xu Wenli;Du Yunhui;Bai Yan;Li Xiao;Yu Haicun;Dong Zhigang;Wang Wen;Liu Huirong

  Background:β_1-adrenoceptor autoantibody(β_1-AA) deeply implicates in cardiac dysfunction.Increased CD4+/CD8+ T cells ratio was found in serum of cardiac dysfunction rat induced by β_1-AA.The present study was designed to test whether T cells are directly related to β_1-AA induced cardiac dysfunction,and if so,to determine the characteristics and underlying mechanisms of every T-cell subset alteration.Methods:First,we observed the influence of β_1-AA on the pathological T cells……