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PDTC inhibits NF - κB activation by inhibiting proteasome activity through the mediation of zinc

Chul Hoon KIM;In Sook KIM;Jinu LEE;Shin Young KANG;Joo Hee KIM;Hyun Soo KIM

   Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-κB).We have previously reported that the effects of pyrrolidine dithiocarbamate (PDTC) on cell death and NF-κB inhibition are zinc dependent (Kim et al,FEBS Lett.449, 28-32,1999, Kim,et al,J. Neurochem.72, 1586-1592,1999),not through its antioxidant effect.In the present study, we sought to characterize the molecular mechanism of PDTC inhibition of NF-κB……