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Pharmacology and clinical effect of Bicyclol——A new anti-hepatitis drug

刘耕陶

   Instiute of Materia Medica,Chinese Academy of Medical Sciences,Beijing,ChinaBicyclol is a synthesized new anti-hepatits drug and has patent protection in 14 developed countries.Bicyclol has actions of anti-hepatitis virus,antiexperimental liver injury and anti-liver fibrosis in mice and rats.Co-incubation of bicyclol with cultivated 2.2.15 cell line inhibited secretion of HBeAg and HbsAg as well as HBV-DNA replication.Bicyclol 0.4,0.6g/kg given P.O.to duck-infected with DHBV significantly reduced serum and liver DHBV-DNA level.Oral administration of bicyclol 50,……