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Effects of aluminium intoxication on immune function in chickens

ZHANG L C;LI Y F~1 (College of Veterinary Medicine;Northeast Agricultural UniversityHarbin;China)

  Model of different level s sub-chronic aluminium poisoning in chickens was established by continuous peritoneal injection of different gradient aluminium trichloride(AlCl_3).The contents of Al,Fe,Zn,Mn,Ca and Cu in serum,spleen and bursa of Fabricius,the contents of Complement 3(C3),Complement 4(C4),Interleukin-2(IL-2) and tumor necrosis factor(TNF-α) in serum were detected.The results showed that the contents of Al,C4 and TNF-αwere higher and the contents of Cu,Zn,Fe,Ca,Mn,C3 and IL-2 were lower in chickens with aluminium intoxication than the control group and the contents had dose-effect relationship with AlCl_3.The results indicated that aluminium intoxication inhibited the immune function of chickens.……