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  Objective:To explore the alleviative effect of soybean yaoflavone compound on physical Fatigue.Methods:160 male ICR mice(18-22g) were divided into four groups:a negative control and three experimental groups,After the mice were oral administered soybean isoflavone compound by dosage 0,0.13, 0.27 and 0.40g/kgBW respectively for 30 days,loaded swimming time,serum urea mitrogen,blood lactic acid and glycogen in liver were determined.Results:0.13,0.27 and 0.40g/kgBW soybean isoflavone compound could significantly prolong the loaded swimming time of mice(4.31,4.41,4.86 vs 2.98 min),while decreasing the area under the blood lactic acid curve(21815.9,22266.2,20572.4 vs 24699.2) and 0.27g/kgBW soybean ivoflavone compound could obviously decrease serum urea nitrogen level after swimming(7.46 vs 8.76 mmol/L).At the same time,0.27 and 0.40g/kg BW soybean isoflavone compound showed an evident incremental effect on rest glycogen in liver(30.0,30.7 vs 23.3 mg/g).Conclusion:soybean isoflavone compound could have effect on alleviating physical fatigue.……