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Comparative enantioseparation of fourteen 1-substituted 3-substituted-2-propanols on polysaccharide-based chiral columns under reversed-phase conditions

Xiao-Qian Han~(1;*);Ping Chen~2;Yan-Hua Liu~1 1 The College of Chemical and Biology Engineering;Lanzhou Jiaotong University;Lanzhou 730070.China;2 Department of chemistry;Anhui Chizhou Teachers College;Chizhou 247100;China

  During the last two decades,enantioseparation has become very important in analytical chemistry,especially in the pharmaceutical and biological fields,because some stereoisomers of racemic drugs have quite different pharmacokinetic properties and different pharmacological or toxicological effects 3.Enantioseparation using chiral stationary phases(CSPs)by high performance liquid chromatography(HpLC)has proven to be the most useful among the methods……