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Evolving Options in Hepatitis B Therapy

Man-Fung Yuen

  The primary goal for treatment of chronic hepatitis B (CHB) infection is to prevent development of cirrhosis-related complications and hepatocellular carcinoma (HCC).It is clear that sustained long-term viral suppression is the key for achieving this goal.Currently,immunomodulators e.g.interferon-alpha and nucleoside/ nucleotide analogues e.g.lamivudine,adefovir,entecavir,telbivudine are the drugs approved for treatment of CHB.Decision on the choice of therapy should be based on the efficacy,resistance profile,safety,method of administration and cost for individual agent.Nucleoside/nucleotide analogues e.g.entecavir and telbivudine with……