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Expression of class Ⅰ MHC molecule,HSP70 and TAP in human hepatocellular carcinoma


   AIM:To demonstrate whether class I MHC molecule,transporter associated with antigen processing(TAP),andheat-shock proteion70(HSP70)expressed in liver cancercells before the design and construction of CTL vaccineagainst hepatocellular carcinoma(HCC).METHODS:We studied 30 HCC specimens by labeledstreptavidin biotin(LSAB)method of immunohistochemistry.RESULTS:The results showed that the majority of HCCcells investigated naturally expressed class I MHC and TAP,which were different from other tumor cells.Furthermore,we found that HSP70 expressed not only in cellularcytoplasm,but also on the cell surface in HCC.CONCLUSION: Our findings indicate that our understanding about immune escape mechanisms employed by HCC cells may be further improved. It is important to design and construct CTL vaccine against HCC.……