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Study on Bioassay-guided Isolation of Cytotoxic Compounds from Bark of Betula albo-sinensis Burk


  [Objective]To study the anti-tumor active ingredients of Betula albo-sinensis Burk.bark.[Method]The compounds were isolated and purified by bioassay-guided procedure using various chromatographic methods and the structures were identified by modern spectroscopic technology.[Result]Five pentacyclic triterpenoids were obtained from the active substances of chloroform extract and identified as lup-20(29)-en-28-ol-3β-yl caffeate(Ⅰ),betulin(Ⅱ),lupeol(Ⅲ),betulinic acid(Ⅳ) and betulonic acid(Ⅴ).All the compounds showed cytotoxic activities on Bel-7402,B16 and A549 cell lines.[Conclusion]All the compounds obtained from this study were isolated from Betula albo-sinensis Burk.firstly.……   
[关键词]:Betula albo-sinensis Burk.;Cytotoxicity;Bioassay-guided isolation;Pentacyclic triterpenoids;China
[文献类型]:期刊
[文献出处]: 《Medicinal Plant2010年08期
[格式]:PDF原版; EPUB自适应版(需下载客户端)