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Effects of Triptolide on Inflammatory Factors in Alzheimer's Disease Cell Model


  [Objective]To observe the preventive and therapeutic effects of T10 on A β1-42 oligomer mediated Alzheimer s Disease(AD) and its mechanism.[Method]The microglia cells were pre-treated with 10-11-10-8 mol/L T10 for 12 h before 10 μmol/L A β1-42 was added in,and incubated for 12 hours together.The content of TNF-α and IL-1β in supernatant were determined by ELISA.The conditioned medium was collected and was added with the hippocampus neurons treating for 24 hours.The survival rate of the neurons was detected by MTT.[Result]T10 could significantly decrease the release of TNF-and IL-1β induced by A β1-42 from microglia in vitro and raise the survival rate of the hippocampus neurons.[Conclusion]T10 could protect the hippocampus neurons through inhibiting the activation of microglia.……   
[关键词]:Alzheimer's Disease;Triptolide;Microglia cell;TNF-α;IL-1β;China
[文献类型]:期刊
[文献出处]: 《Medicinal Plant2010年08期
[格式]:PDF原版; EPUB自适应版(需下载客户端)