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LC/MS/MS法同时测定卷烟主流烟气中4种TSNAs

毛友安;钟科军;魏万之;卢红兵;魏新亮

  A liquid chsomatographic-tandem mass spectrometric method was used to simultaneously determine four tobacco-specific nitrosamines in cigarette mainstream smoke.Cigarette smoke particulate,obtained under standardized machine smoking,was collected on a Cambridge filter pad.The particulate was co-extracted with citric acid-phosphate buffer and cyclohexane and further purified by solid-phase extraction.Analyte identification and quantification were performed using multiple reaction monitoring with one precursor ion and two product ions as identifiers and electrospray ionization in positive mode.The limits of detection were in the range of 0.05~0.24ng/mL using an injection volume of 20μL,linear range over 2.5~1000ng/mL,linear correlation coefficients above 0.998,and recoveries 90.2%~95.1%.……   
[关键词]:LC/MS/MS;烟草特有亚硝胺;卷烟主流烟气;多反应监测
[文献类型]:期刊
[文献出处]: 《化学研究与应用2005年04期
[格式]:PDF原版; EPUB自适应版(需下载客户端)