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Influence of HLA class Ⅱ molecules on the outcome of hepatitis B virus infection in population of Zhejiang Province in China


   OBJECTIVE: To investigate the correlation between HLA class Ⅱ molecules and the different outcome ofviral hepatitis B.METHODS: Thirty patients with chronic hepatitis B and 56 subjects who had spontaneously recoveredfrom HBV infection in Zhejiang were enrolled in this investigation. HLA class Ⅱ molecules types andalleles were determined by PCR-ssp.RESULTS: HLA-DR12 was found in 21 of the 56 subjects (38%) recovered from hepatitis B, comparedto 3 of the 30 patients with chronic hepatitis B [10%, relative risk (rr), O.19; P_(corr)<0.025]. Thefrequency of the allele of HLA-DR12 DRBl~* 1201 was higher in the subjects recovered from hepatitis Binfection (32%) than in the patients with chronic hepatitis B (3%; rr, 0.07; P_(corr)<0.005). On thecontrary, more HLA-DR9 was detected in the patients with chronic hepatitis B (43%) than in the subjectswho recovered from hepatitis B infection (18%; rr, 3.52; P_(corr)<0.025). HLA-DQ9 was also detectedwith a higher frequency in the patients with chronic hepatitis B (43%) than in the subjects who recoveredfrom hepatitis B (20%; rr, 3.13; P_(corr)<0.05).CONCLUSIONS: The HLA class Ⅱ molecule DR12 and its allele DRBl~* 1201 are associated withprotection against chronic hepatitis B in Zhejiang Province, China. HLA-DR9 and DQ9 are associatedwith chronicity of HBV infection.……   
[关键词]:HLA;hepatitis B;allele
[文献类型]:期刊
[文献出处]: 《Hepatobiliary Pancreatic Diseases International2003年02期