手机知网 App
24小时专家级知识服务
打 开
手机知网|搜索

First Total Synthesis of Hyacinthacine A_6 from the Protected Derivative of Polyhydroxylated Pyrrolidine


  (1S,2R,3R,5R,7aR)-1,2-Dihydroxy-3-hydroxymethyl-5-methylpyrrolizidine(hyacinthacine A6,1) was synthesized by Wittig s methodology via the reaction of aldehyde 6,prepared from the partially protected derivative of polyhydroxylated pyrrolidine,with appropriated ylides,followed by cyclization through the internal reductive amination process of the resulting α,β-unsaturated ketone 7,and total deprotection.……   
[关键词]:Hyacinthacine A6;Pyrrolidines;Wittig reaction;Cyclization
[文献类型]:期刊
[文献出处]: 《Chemical Research in Chinese Universities2008年04期
[格式]:PDF原版; EPUB自适应版(需下载客户端)