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Synthesis,Characterization,and DNA Binding Properties of Dinuclear Copper(Ⅱ) Complex [Cu_2(TATP)_2(L-Leu)_2(ClO_4)_2]_2·2H_2O


  A dinuclear copper(Ⅱ) complex [Cu2(TATP)2(L-Leu)2(ClO4)2]2·2H2O was synthesized and characterized,where,TATP=1,4,8,9-tetraazatriphenylene,and L-Leu=L-leucinate. The complex was crystallized in the triclinic space group P1,with two independent molecules in a unit cell. Two Cu(Ⅱ) ions in each complex [Cu2(TATP)2(L-Leu)2(ClO4)2] molecule were found to be in different coordination geometries,i.e.,Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of TATP,the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate,and Cu1 or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms,and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalative mode and cleave pBR322 DNA in the presence of ascorbate.……   
[关键词]:Copper(Ⅱ) complex;1;4;8;9-Tetraazatriphenylene;L-Leucinate;DNA
[文献类型]:期刊
[文献出处]: 《Chemical Research in Chinese Universities2008年04期
[格式]:PDF原版; EPUB自适应版(需下载客户端)