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The b2/b3 partial deletion shows higher frequency of complete AZFc deletion than the gr/gr partial deletion in Han Chinese population

Chuncheng Lu;Yankai Xia;Yingchun Li;Wei Wu;Guixiang Ji;Aihua Gu;Shoulin Wang;Ling Song;Xinru Wang. Key Laboratory of Reproductive Medicine;Institute of Toxicology;Nanjing Medical University;Nanjing 210029;China.

  Objective:In order to investigate the roles of partial deletions in impaired spermatogenesis and the relationship between the complete and partial AZFc deletions. Methods:Y chromosome AZFc deletion typing and Y chromosome haplogrouping in 756 idiopathic infertile Han-Chinese and 391 healthy Han-Chinese were performed.Results:We found that the b2/b3 partial deletion was associated with spermatogenic failure.And we also confirmed that two previously reported fixations,the b2/b3 deletion in haplogroup N1 and the gr/gr deletion in haplogroup Q1. Remarkably,the frequency of the complete AZFc deletion in haplogroup N1 was significantly higher than that in the haplogroup Q1.……