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Regulation of Mesenchymal Stem Cells by glycolipid in Organ Fibrosis

李凌松

  We have previously reported that sphingosine 1-phosphate(S1P) regulates the migration of mesenchymal stem cells(MSCs) from the mouse bone-marrow into the damaged liver.Using green-color MSCs isolated from GFP-transgenic mice,here we show that inhibition of SIP signaling by FTP720,a functional inhibitor for S1P receptors,S1P1 and S1P3,significantly blocks migration of mouse MSCs and improves conditions in chemically induced fibrotic liver.In addition,we also found MSCs contributing to the lung fibrosis and this process is regulated by lysophosphatidic acid(Lpa),another cell metabolite glycolipid. Our study will bring cautious for the safety of MSC transplantation,and provide S1P and Lpal as new targets for potentially treating fibrosis.……   
[关键词]:
[文献类型]:会议论文
[文献出处]: 《急慢性创面治疗新技术专题系列研讨会之感染创面综合治疗论坛论文汇编2011年