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Sites of interaction of thioredoxin with Bacillus subtilis Methionine sulfoxide reductase A(MsrA)

Saudrine BOSCHI-MULLER;Guy BRANLANT

  Methionine(Met) oxidation into Methionine sulfoxide(MetSO) is involved many pathologies and to exert regulatory effects on proteins. This oxidation can be reversed by a ubiquitous enzyme, the peptide Methionine sulfoxide reductase A (MsrA), and the regeneration of MsrA activity requires the thioredoxin (Trx) recycling system in vivo. Trx recycling system is capable of catalysing the reduction of disulfide bond on proteins through……